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Research Core Facilities

2019researchmagazine

The UMass Boston core facilities bring cutting-edge instrumentation, methodologies and expertise to our research community. 这些设施不仅由我们的内部专家提供高质量的研究服务,而且为我们不断发展的研究事业提供了重要的教育资源. Operating as fee-for-service facilities, some are available to external researchers as well.

UMass Boston Core Facilities Innovation Voucher Program
A state voucher program funded by the Massachusetts legislature gives small and medium-sized businesses (<50 FTEs) access to the University’s leading-edge research facilities at reduced rates. All UMass Boston core facilities are available for use with the voucher program.

Voucher Eligibility

  • Companies with 50 or less FTEs, headquartered in Massachusetts and registered to do businesses in Massachusetts with the Secretary
  • Start-ups and companies with 10 or fewer employees receive a 75% subsidy.
  • Start-ups and companies with 11-50 employees receive a 50% subsidy

UMass Core Facilities Benefits

  • Highly competitive rates
  • Managed by full-time experienced professionals
  • Tiered access to equipment and services
  • Streamlined contracts
  • State-of-art facilities and equipment

For information about the UMass Boston core facilities or the Voucher Program, contact: Serena.Wang@casque-beatsbydrer.com  


Genomics Core Facility

The Genomics Core 服务模式通过提供量身定制的服务,将早期想法从可行性评估转移到项目完成,填补了基因组学研究的关键空白. We provide an accessible venue for exploratory, high risk / potentially high pay-off genomics-based studies, especially those that require innovative and/or technically challenging approaches. Do you have an idea that might benefit from single-cell, high-throughput, or re-sequencing approaches? Or secondary validation of gene expression levels using novel technologies like NanoString? Give us a call or shoot us an email! We're here to help you.

Equipment

  • Illumina NextSeq 2000
  • Agilent 2100 Bioanalyzer
  • Agilent 2200 Tapestation
  • Qubit
  • Nanodrop Lite
  • Nanostring nCounter Analysis System
  • Quantstudio 12K Flex Real-Time PCR System

Contact
Email: genomicscore@casque-beatsbydrer.com
Phone: 617-287-6578
PI: Jill Macoska
Website: http://26eb.casque-beatsbydrer.com/genomicscore


Vivarium Core Facility

动物资源核心设施和Vivarium致力于为研究和教学中使用的动物提供最高水平的护理. 动物研究的所有方面都由澳门新葡新京官方机构动物护理和使用委员会(IACUC)审查,并由研究和赞助项目办公室监督.

澳门官方老葡京校区综合科学中心最先进的动物园内为特定的无病原体物种提供了住所,包括, rodents, frogs, reptiles, and zebra fish.  The vivarium consists of a total 7,515 square feet space with 2,744 square feet of dedicated animal housing.  The floor plan is of a single corridor design with branching corridors to the cage wash room, various procedure and housing rooms, behavioural test rooms, and suites. 

Monitoring and environment controls
With the exception of the independently controlled housing cubicles, the vivarium is controlled and monitored for climate by the Building Monitoring System (BMS). 动物园内的照明是可编程的,有多种强度设置,以适应工作人员和动物. The individually ventilated rodent housing system (IVC) has standard cages and contact-bedding. Security is maintained through camera surveillance and a key-card entry system controlled by the BMS.

Contact
Contact Us

Facility Manager: Elizabeth Boates
Website: http://26eb.casque-beatsbydrer.com/arcf


Proteomics Core Facility

澳门官方老葡京蛋白质组学中心以极具竞争力的价格使用Orbitrap Fusion Lumos Tribrid质谱仪提供全方位的蛋白质组学服务. Our services range from sample preparation, bottom-up protein identification, quantification of expression levels using both label free and TMT multiplexing strategies, PTM analysis, 2D fractionation, and top-down proteomic analysis. 我们的仪器在设计蛋白质组学实验方面提供了独特的灵活性,为您的项目提供最佳结果. The director of the core, Professor Jason Evans, has over 25 years of experience in the field of mass spectrometry and proteomics, 自2016年春季以来,我们一直服务于澳门新葡新京官方多名主要研究人员的蛋白质组学需求. We offer unmatched customer service, 花时间与您协商,了解您的需求,并制定分析您的样品的最佳计划, so that you get the most out of the resulting data. We work very hard to keep our turn-around times as short as possible. In addition, as a core facility at the University of Massachusetts Boston, 我们目前处于一个独特的位置,为员工少于10人的小企业提供75%的折扣,为员工少于50人的小企业提供马萨诸塞州政府补贴的50%折扣.

Equipment
The Proteomics Core currently uses the state-of-the-art Orbitrap Fusion Lumos Tribird mass spectrometer with the Easy-ETD upgrade coupled with either an Easy-nLC 1200 or an UltiMate 3000RS HPLC. The core uses the Thermo Xcalibur suite of programs to run the equipment and analyze the raw data files. For bottom-up studies the core uses Thermo Proteome Discoverer to identify and/or quantify the expressed proteins in the client's sample(s). For top-down studies the core uses the ProSightLite application.

Contact
Email: Proteomics.Core@casque-beatsbydrer.com 
Phone: 617-287-6149
PI:  Jason Evans
Website: http://26eb.casque-beatsbydrer.com/proteomicscore


Imaging Core Facility

Imaging Core is equipped with a confocal microscope by Zeiss, 这是一个在校园创业发展中心向马萨诸塞大学社区和成员公司开放的共享资源.

Contact
Email: Alexey.Veraksa@casque-beatsbydrer.com
PI:  Alexey Veraksa
Website: Veraksa Lab (casque-beatsbydrer.com)


Environmental Analytical Core Facility

提供最先进的环境仪器的化学和材料性质分析的环境样品,包括天然水, soils, sediments, and biological tissues. 该设备包括两台电感耦合等离子体质谱仪(一台四极杆仪器和一台高分辨率仪器), magnetic sector instrument), isotope ratio mass spectrometer, GC mass spectrometer, and several peripherals (e.g., laser ablation, HPLC) for hyphenated metal analyses of solids and aqueous speciation. 一个100级(ESO 5)洁净室设施和几个100级洁净工作台是该设施的一部分. 核心设施还包括扫描(SEM)和场发射(FESEM)扫描电子显微镜和纳米工程材料表征的技术专长, microelectronics, and others.

Equipment

  • Isotope Ratio Mass Spectrometer (IRMS)
  • Gas Chromatography Mass Spectrometer (GC-MS)
  • Inductively Coupled Plasma Mass Spectrometer (ICP-MS)
  • ICP-MS peripherals and processing equipment
  • Electron Microscopy
  • Microscopy
  • Elemental Analyzer (EA)
  • Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES)
  • Cold Vapour Atomic Fluorescence Spectroscopy (CVAFS)
  • Fourier Transform Infrared Spectroscopy (FTIR)
  • Mercury Analyzers
  • Sediment Digestion Systems
  • Dissolved Inorganic/Organics
  • UV-Vis Spectrometers
  • Fluorometer
  • Digital Microbalances
  • ED-XRF

Contact
Email: EACF@casque-beatsbydrer.com
Phone: 617-287-5562
PI: Karen Johannesson
Website:  http://26eb.casque-beatsbydrer.com/eaf


Biophysical Instrumentation Core Facility

生物物理仪器核心设施配备了最先进的仪器,以帮助研究人员表征分子相互作用, sample integrity, stability, structure, and more. The Core is open to both internal and external users.

  • Fluorescence and fluorescence anisotropy
  • Circular dichrosim (CD) and LD spectroscopy
  • Absorbance spectroscopy
  • Binding affinity (KD)
  • Dynamic light scattering (DLS) and multi angle light scattering (MALS)
  • Isothermal titration calorimetry (ITC)
  • Differential Scanning Calorimetry (DSC)

Contact
Email: bic@casque-beatsbydrer.com
PI: Daniel Dowling
Website: http://26eb.casque-beatsbydrer.com/bic


Quantum Hardware Development & Commercialization Core Facility

量子核心设施为量子设备的开发和商业化提供了访问马萨诸塞州波士顿的量子设备表征和制造设施的量子信息科学和工程行业. 量子器件制造能力包括1000级洁净室设施,具有电子束和光学光刻能力,以及超导金属的电子束和溅射沉积工艺. Packaging and characterization capabilities include atomic force microscopy, scanning electron microscopy, 4-point probe stations, and wire bonders. Low temperature measurement systems include two-cryogen free dilution refrigerators, Helium-3 cryostat and 4 K cryostats for DC and RF measurements. A suite of measurement electronics including high frequency vector network analysers, spectrum analysers, 微波合成器和直流电源可用于量子器件的低温电特性. 量子核心上量子器件的表征可以通过远程方式完成,并且可以通过网络访问测量计算机和电子设备. Technical expertise is also available through the core facility.

Contact
Email: Matthew.Bell@casque-beatsbydrer.com
PI:  Matthew Bell


Scanning Electron Microscope (FESEM) Core Facility

蔡司Sigma500VP FESEM是一种先进的场发射SEM,可在高和低加速电压下产生出色的图像. Together with its analytical capabilities, this instrument is suitable for a wide range of applications. 仪器配有高分辨率场发射柱和高稳定性肖特基场炮, the beam current ranges from 1 pA to 400 nA, and the acceleration voltage range is from 200 eV to 30 keV.

Detectors: In-lens secondary electron, Everhart-Thornley secondary electron, variable pressure secondary electron, backscattered electron. 

该仪器配备了牛津能量色散光谱(EDS)系统,用于扫描电镜内样品的元素和化学分析. 

Contact
Email: SEM@casque-beatsbydrer.com
PI: Niya Sa
Website:  http://saniyabnu.wixsite.com/niyasa


AI Core Facility

人工智能核心为大规模数据收集的机器学习提供基础设施和算法. 服务包括专门的数据管理和有针对性的软件开发,以尽量减少人工数据处理的成本.

Contact:
Email: daniel.haehn@casque-beatsbydrer.com
PI: Daniel Haehn
Website: http://mpsych.org/


Flow Cytometry Core Facility

流式细胞仪核心设施使澳门新葡新京官方的研究人员和学术和行业合作者能够开展基础和转化细胞和分子生物学研究.  We leverage cutting-edge technologies for research and clinical applications.  We help investigators and clinicians analyze tissue samples, 根据细胞特异性荧光标记的存在,鉴定和量化不同的细胞群, and collect cellular populations of interest for further analysis.

Equipment
BD FACSAria Fusion:  The Aria Fusion is an avid cell sorter and analyzer. 

Contact
Email: ORSP@casque-beatsbydrer.com
Phone: 617-287-3956
Website: http://26eb.casque-beatsbydrer.com/flowcytometrycore